Definitely agree on a few points. The slate will be wiped clean and no one is guaranteed a starting position. I think Frost wants to play "his guys." That is the new recruits if they are ready. Especially the JUCO guys.
I think that the QB Milton and RBs will get significant playing time, unless Milton redshirts as Frost sort of plays this off as a "transition" year and lets a senior QB start and finish the year. Also, I wouldn't count out Dinovo as crazy as it may sound.
As far as NFL players. I think we will have significantly less and I'm not really sure that's a bad thing. Frost's type of players may not be the best NFL ready players, but more significantly, we won't have as many guys leave early. The NFL may not rate say a 175-185lb junior RB or an undersized lineman very highly for the draft, forcing the kid to come back for his senior season.