| Second Round — Sunday, March 20 | ||||
| No. 4 Illinois vs. No. 5 Houston | 12:10 p.m. | CBS | Pittsburgh, Pennsylvania | PPG Paints Arena |
| No. 2 Villanova vs. No. 7 Ohio State | 2:40 p.m. | CBS | Pittsburgh, Pennsylvania | PPG Paints Arena |
| No. 2 Duke vs. No. 7 Michigan State | 5:15 p.m. | CBS | Greenville, South Carolina | Bon Secours Wellness Arena |
| No. 3 Wisconsin vs. No. 11 Iowa State | 6:10 p.m. | TNT | Milwaukee, Wisconsin | Fiserv Forum |
| No. 3 Texas Tech vs. No. 11 Notre Dame | 7:10 p.m. | TBS | San Diego, California | Viejas Arena |
| No. 2 Auburn vs. No. 10 Miami (Fla.) | 7:45 p.m. | truTV | Greenville, South Carolina | Bon Secours Wellness Arena |
| No. 3 Purdue vs. No. 6 Texas | 8:40 p.m. | TNT | Milwaukee, Wisconsin | Fiserv Forum |
| No. 1 Arizona vs. No. 9 TCU | 9:40 p.m. | TBS | San Diego, California | Viejas Arena |
