I have the Harmony Smart Control that Sublime referenced. Essentially, you set up the IR blaster hub via Wi-Fi, sync your various devices to it through your online Logitech account and you're good to go. It comes with a small remote and you can download an app to also control the hub/devices. I actually like the remote a whole lot better than the old remotes with the small lcd screen; it uses a regular watch battery (and because of no screen, lasts a whole lot longer) and is more comfortable to hold. The controls in the app are completely customizable.
The one thing I will say, though, is you mentioned multiroom setups and I'm not sure if it can accommodate that in an easy (or cost effective) manner. Each hub has to have a unique name, as far as I know. I imagine you can hook up multiple ones to a wifi network and control through a single account/app, but you would have to switch over the connected hub each time you went into another room. I have thought about getting a longer cable for the included additional blaster to run into another room, don't know how that would work out, though.
Also, regarding syncing, the only issue I've had with mine is staying synced w/ my PS3. It drops from time to time (An issue that seems universal to logitech remotes) and has to be re-registered.