OT: New Drug Reverses Neural and Cognitive Effects of a Concussion

[FormerlyKnightInAtlanta]

Given that in contact sports like football concussions are actively common, I thought this was good news to share. Minimizing the impacts of brain injuries can proactively help the lives of untold numbers of people around the globe.

New Drug Reverses Neural and Cognitive Effects of a Concussion

UCSF researchers use ISRIB to block the molecular stress response in order to restore cognitive function. ISRIB, a tiny molecule identified by the University of California, San Francisco (UCSF) researchers can repair the neural and cognitive effects of concussion in mice weeks after the damage, acc

scitechdaily.com

ISRIB, a tiny molecule identified by the University of California, San Francisco (UCSF)researchers can repair the neural and cognitive effects of concussion in mice weeks after the damage, according to a new study.

ISRIB blocks the integrated stress response (ISR), a quality control process for protein production that, when activated chronically, can be harmful to cells.


The study, which was recently published in the Proceedings of the National Academy of Sciences, discovered that ISRIB reverses the effects of traumatic brain injury (TBI) on dendritic spines, an area of neurons vital to cognition. The drug-treated mice also showed sustained improvements in working memory.

 

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