Yet another study showing that vax'ing with the 2 year-old spike no longer found in the wild may actually be causing ADE.
I.e., by not updating the vaccine, the unvaccinated or unboosted may actually be more protected.
This was always the fear, and the primary complaint by the (now resigned) FDA experts when Pfizer's CEO announced Boosters that were not updated, as the FDA (had previously) required for Boosters.
Sigh... this isn't an anti-vax argument, but a pro-'update the vax' argument, instead of letting Pharma push old stock of 2 year-old, out-of-date, vaccines.
Antibody dependent enhancement (ADE) of infection is a safety concern for vaccine strategies. In a recent publication, Li et al. (Cell 184 :4203-4219, 2021) have reported that infection-enhancing antibodies directed against the N-terminal domain (NTD) of the SARS-CoV-2 spike protein facilitate...
pubmed.ncbi.nlm.nih.gov