Since the Civil War pretty much settled the issue, yes all states are going to be bound by it. As for whether we are willing to fight a war over it in this day and age, I have no idea. The problem is that we’re either heading for a cultural war or we’re already in one and the ideologies in contention are intermingled in all of the states. So unless there is a migration that runs counter to the current exodus from many blue states, then I don’t think that you’re going to see secession any time soon.