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Hundreds of Millions of People Have Safely Received a COVID-19 Vaccine​


More than 558 million doses of COVID-19 vaccine had been given in the United States from December 14, 2020, through March 21, 2022. To view the current total number of COVID-19 vaccinations that have been administered in the United States, please visit the CDC COVID Data Tracker.
COVID-19 vaccines are safe and effective. COVID-19 vaccines were evaluated in tens of thousands of participants in clinical trials. The vaccines met the Food and Drug Administration’s (FDA’s) rigorous scientific standards for safety, effectiveness, and manufacturing quality needed to support emergency use authorization (EUA). Learn more about EUAs in this video.external icon
The Pfizer-BioNTech, Moderna, and Johnson & Johnson/Janssen COVID-19 vaccines will continue to undergo the most intensive safety monitoring in US history. This monitoring includes using both established and new safety monitoring systems to make sure that COVID-19 vaccines are safe.

Common Side Effects​

After COVID-19 vaccination, some people may feel ill, with symptoms like fever or tiredness for a day or two after receiving the vaccine. These symptoms are normal and are signs that the body is building immunity. Some people have no side effects. Others have reported common side effects after COVID-19 vaccination,such as:
  • Swelling, redness, and pain at the injection site
  • Fever
  • Headache
  • Tiredness
  • Muscle pain
  • Chills
  • Nausea

Serious Safety Problems Are Rare​

In rare cases, people have experienced serious health events after COVID-19 vaccination. Any health problem that happens after vaccination is considered an adverse event. An adverse event can be caused by the vaccine or can be caused by a coincidental event not related to the vaccine.
 

Hospitalizations in Largest Trial to Date​

Patients who got the antiparasitic drug didn’t fare better than those who received a placebo​

im-506883

Ivermectin got attention from celebrities including podcast host Joe Rogan, but researchers said they found no indication that it is clinically useful against Covid-19.
PHOTO: MIKE STEWART/ASSOCIATD PRESS
I By

Sarah Toy
Updated March 18, 2022 10:16 am ET

Researchers testing repurposed drugs against Covid-19 found that ivermectin didn’t reduce hospital admissions, in the largest trial yet of the effect of the antiparasitic on the disease driving the pandemic.
Ivermectin has received a lot of attention as a potential treatment for Covid-19 including from celebritiessuch as podcast host Joe Rogan. Most evidence has shown it to be ineffectiveagainst Covid-19 or has relied on data of poor quality, infectious-disease researchers said. Public-health authorities and researchers have for months said the drug hasn’t shown any benefit in treating the disease. Taking large doses of the drug is dangerous, the Food and Drug Administration has said.
The latest trial, of nearly 1,400 Covid-19 patients at risk of severe disease, is the largest to show that those who received ivermectin as a treatment didn’t fare better than those who received a placebo.

SHARE YOUR THOUGHTS​

How should the most recent studies on the efficacy of ivermectin against Covid-19 influence its use going forward? Join the conversation below.
“There was no indication that ivermectin is clinically useful,” said Edward Mills, one of the study’s lead researchers and a professor of health sciences at Canada’s McMaster University in Hamilton, Ontario. Dr. Mills on Friday plans to present the findings, which have been accepted for publication in a major peer-reviewed medical journal, at a public forum sponsored by the National Institutes of Health.
Dr. Mills and his colleagues looked at 1,358 adults who visited one of 12 clinics in the Minas Gerais region of Brazil with Covid-19 symptoms. The patients all had a positive rapid test for SARS-CoV-2, and were at risk of having a severe case for reasons including a history of diabetes, hypertension, cardiovascular disease or lung disease.
im-506882

Poster with the phrase, ‘We have ivermectin,’ at a pharmacy in Ceilândia, Brazil.
PHOTO: RICARDO JAYME/AGIF/ASSOCIATED PRESS
The researchers prescribed half of the patients a course of ivermectin pills for three days. The other half received a placebo. They tracked whether the patients were hospitalized within 28 days. The researchers also looked at whether patients on ivermectin cleared the virus from their bodies faster than those who received a placebo, whether their symptoms resolved sooner, whether they were in the hospital or on ventilators for less time and whether there was any difference in the death rates for the two groups.
To make sure they were being thorough, the researchers analyzed the data in three different ways. They looked at data from all patients; then analyzed data from patients who received ivermectin or a placebo 24 hours before they were hospitalized; and in a third review, looked at data from patients who said they had adhered strictly to their dosing schedule. In each scenario, they found ivermectin didn’t improve patient outcomes.
“This is the first large, prospective study that should really help put to rest ivermectin and not give any credibility to the use of it for Covid-19,” said Peter Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine, who reviewed the findings.
Ivermectin is used primarily to treat patients with certain parasitic diseases. Some doctors have been prescribing it to Covid-19 patients, and some people have been found ways to obtain ivermectin without a prescription. The drug has antiviral properties, but hasn’t been approved by the FDA to treat any viral infections.
Given its antiviral prospects, scientists early in the pandemic thought it could be a candidate for treating Covid-19. In June 2020, a group of researchers in Australia published a paper showing that large amounts of ivermectin could halt replication of the coronavirus in cell cultures. But there was a problem: To achieve that effect, a person would have to take up to 100 times as much ivermectin as the dose approved for use in humans.
Some studies on ivermectin published in journals or on preprint servers ahead of peer review have demonstrated no benefits, or worsening of Covid-19 symptoms, after ivermectin use. Some have shown some benefit, such as shorter time to symptom resolution, reduction in inflammation, faster viral clearance and lower death rates.
im-506884

Ivermectin capsules, seen last year in the Philippines, where the drug was distributed in some places despite a lack of evidence to show it prevents or cures Covid-19.
PHOTO: ROLEX DELA PENA/SHUTTERSTOCK
But most studies showing positive effects had significant limitations such as small sample sizes or poorly defined outcomes, according to the NIH. Several studies on ivermectin have been withdrawn from publication, including a randomized controlled trial looking at 100 patients in Lebanon that was retracted by the journal Virusesdue to issues with the statistical analysis, according to the journal. Researchers at the NIH and Oxford University also are conducting large trials on the effectiveness of ivermectin, though results haven’t been published.
Dr. Mills said ivermectin could improve outcomes in Covid-19 patients who are fighting off certain parasitic diseases at the same time. But based on his team’s findings, he said, the drug doesn’t seem to have any effect on Covid-19 itself.
Dr. Mills and his colleagues also are studying other drugs that could be repurposed to work against Covid-19. Such drugs could be useful because their side effects are well known and they may be cheaper to deploy in poor countries than drugs like Merck & Co. and Ridgeback Biotherapeutics LP’s molnupiravir or Pfizer Inc.’s Paxlovid.

Related Video​

secondboosterisrael_512x288.jpg

Amid a surge in cases, some countries are handing out second booster shots. In Israel, early data suggest a fourth vaccine dose can increase antibodies against Covid-19, but not enough to prevent infections from Omicron. WSJ explains. Photo composite: Eve Hartley/WSJTHE WALL STREET JOURNAL INTERACTIVE EDITION
Merck said it has taken steps to make molnupiravir available in low- and middle-income countries, including allocating three million courses for distribution through aid groups and granting licenses to generic manufacturers. Pfizer said it was working to expand its supply chain and licensing production of Paxlovid through a United Nations program.
Dr. Mills and his collaborators have looked at 11 repurposed treatments against Covid-19, of which at least one has shown promise—fluvoxamine, which is commonly used to treat obsessive compulsive disorder and depression. They published the research in the Lancet Global Health in October, showing that Covid-19 patients who received fluvoxamine were less likely to require hospitalization than those who didn’t.
The researchers are looking at the effect in Covid-19 patients of combining fluvoxamine and an inhaled steroid, budesonide, as well as a drug called peginterferon lambda, which is used to treat chronic viral hepatitis
 
 
Congratulations. The circlejerk boys have completely destroyed the WC with their incessant BS posts

Crazyhole and Knighttime wake up together early on a Sunday morning and instead of making interesting, intelligent threads and posts, they litter this board with a bunch of undebatable nonsense

@Crazyhole
@KNIGHTTIME^
@UCFBS
@Boston.Knight
 
Last edited:
The vaccines are safe and effective. The entire world needs to get vaccinated. No age nor health restrictions to be considered. Man created this mess, and only man can fix it. *
Wise words spoken from a guy who’s succumbed to the first generation of Kreepy Kraulys
 
The vaccines are safe and effective. The entire world needs to get vaccinated. No age nor health restrictions to be considered. Man created this mess, and only man can fix it. *
Yes they are. Thats why everyone should get 17 of them next week.***
 
Yes they are. Thats why everyone should get 17 of them next week.***

Hundreds of Millions of People Have Safely Received a COVID-19 Vaccine​


More than 558 million doses of COVID-19 vaccine had been given in the United States from December 14, 2020, through March 21, 2022. To view the current total number of COVID-19 vaccinations that have been administered in the United States, please visit the CDC COVID Data Tracker.
COVID-19 vaccines are safe and effective. COVID-19 vaccines were evaluated in tens of thousands of participants in clinical trials. The vaccines met the Food and Drug Administration’s (FDA’s) rigorous scientific standards for safety, effectiveness, and manufacturing quality needed to support emergency use authorization (EUA). Learn more about EUAs in this video.external icon
The Pfizer-BioNTech, Moderna, and Johnson & Johnson/Janssen COVID-19 vaccines will continue to undergo the most intensive safety monitoring in US history. This monitoring includes using both established and new safety monitoring systems to make sure that COVID-19 vaccines are safe.

Common Side Effects​

After COVID-19 vaccination, some people may feel ill, with symptoms like fever or tiredness for a day or two after receiving the vaccine. These symptoms are normal and are signs that the body is building immunity. Some people have no side effects. Others have reported common side effects after COVID-19 vaccination,such as:
  • Swelling, redness, and pain at the injection site
  • Fever
  • Headache
  • Tiredness
  • Muscle pain
  • Chills
  • Nausea

Serious Safety Problems Are Rare​

In rare cases, people have experienced serious health events after COVID-19 vaccination. Any health problem that happens after vaccination is considered an adverse event. An adverse event can be caused by the vaccine or can be caused by a coincidental event not related to the vaccine.
 


It's almost like this was inevitable......

Hundreds of Millions of People Have Safely Received a COVID-19 Vaccine​


More than 558 million doses of COVID-19 vaccine had been given in the United States from December 14, 2020, through March 21, 2022. To view the current total number of COVID-19 vaccinations that have been administered in the United States, please visit the CDC COVID Data Tracker.
COVID-19 vaccines are safe and effective. COVID-19 vaccines were evaluated in tens of thousands of participants in clinical trials. The vaccines met the Food and Drug Administration’s (FDA’s) rigorous scientific standards for safety, effectiveness, and manufacturing quality needed to support emergency use authorization (EUA). Learn more about EUAs in this video.external icon
The Pfizer-BioNTech, Moderna, and Johnson & Johnson/Janssen COVID-19 vaccines will continue to undergo the most intensive safety monitoring in US history. This monitoring includes using both established and new safety monitoring systems to make sure that COVID-19 vaccines are safe.

Common Side Effects​

After COVID-19 vaccination, some people may feel ill, with symptoms like fever or tiredness for a day or two after receiving the vaccine. These symptoms are normal and are signs that the body is building immunity. Some people have no side effects. Others have reported common side effects after COVID-19 vaccination,such as:
  • Swelling, redness, and pain at the injection site
  • Fever
  • Headache
  • Tiredness
  • Muscle pain
  • Chills
  • Nausea

Serious Safety Problems Are Rare​

In rare cases, people have experienced serious health events after COVID-19 vaccination. Any health problem that happens after vaccination is considered an adverse event. An adverse event can be caused by the vaccine or can be caused by a coincidental event not related to the vaccine.
 

Hospitalizations in Largest Trial to Date​

Patients who got the antiparasitic drug didn’t fare better than those who received a placebo​

im-506883

Ivermectin got attention from celebrities including podcast host Joe Rogan, but researchers said they found no indication that it is clinically useful against Covid-19.
PHOTO: MIKE STEWART/ASSOCIATD PRESS
I By

Sarah Toy
Updated March 18, 2022 10:16 am ET

Researchers testing repurposed drugs against Covid-19 found that ivermectin didn’t reduce hospital admissions, in the largest trial yet of the effect of the antiparasitic on the disease driving the pandemic.
Ivermectin has received a lot of attention as a potential treatment for Covid-19 including from celebritiessuch as podcast host Joe Rogan. Most evidence has shown it to be ineffectiveagainst Covid-19 or has relied on data of poor quality, infectious-disease researchers said. Public-health authorities and researchers have for months said the drug hasn’t shown any benefit in treating the disease. Taking large doses of the drug is dangerous, the Food and Drug Administration has said.
The latest trial, of nearly 1,400 Covid-19 patients at risk of severe disease, is the largest to show that those who received ivermectin as a treatment didn’t fare better than those who received a placebo.

SHARE YOUR THOUGHTS​

How should the most recent studies on the efficacy of ivermectin against Covid-19 influence its use going forward? Join the conversation below.
“There was no indication that ivermectin is clinically useful,” said Edward Mills, one of the study’s lead researchers and a professor of health sciences at Canada’s McMaster University in Hamilton, Ontario. Dr. Mills on Friday plans to present the findings, which have been accepted for publication in a major peer-reviewed medical journal, at a public forum sponsored by the National Institutes of Health.
Dr. Mills and his colleagues looked at 1,358 adults who visited one of 12 clinics in the Minas Gerais region of Brazil with Covid-19 symptoms. The patients all had a positive rapid test for SARS-CoV-2, and were at risk of having a severe case for reasons including a history of diabetes, hypertension, cardiovascular disease or lung disease.
im-506882

Poster with the phrase, ‘We have ivermectin,’ at a pharmacy in Ceilândia, Brazil.
PHOTO: RICARDO JAYME/AGIF/ASSOCIATED PRESS
The researchers prescribed half of the patients a course of ivermectin pills for three days. The other half received a placebo. They tracked whether the patients were hospitalized within 28 days. The researchers also looked at whether patients on ivermectin cleared the virus from their bodies faster than those who received a placebo, whether their symptoms resolved sooner, whether they were in the hospital or on ventilators for less time and whether there was any difference in the death rates for the two groups.
To make sure they were being thorough, the researchers analyzed the data in three different ways. They looked at data from all patients; then analyzed data from patients who received ivermectin or a placebo 24 hours before they were hospitalized; and in a third review, looked at data from patients who said they had adhered strictly to their dosing schedule. In each scenario, they found ivermectin didn’t improve patient outcomes.
“This is the first large, prospective study that should really help put to rest ivermectin and not give any credibility to the use of it for Covid-19,” said Peter Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine, who reviewed the findings.
Ivermectin is used primarily to treat patients with certain parasitic diseases. Some doctors have been prescribing it to Covid-19 patients, and some people have been found ways to obtain ivermectin without a prescription. The drug has antiviral properties, but hasn’t been approved by the FDA to treat any viral infections.
Given its antiviral prospects, scientists early in the pandemic thought it could be a candidate for treating Covid-19. In June 2020, a group of researchers in Australia published a paper showing that large amounts of ivermectin could halt replication of the coronavirus in cell cultures. But there was a problem: To achieve that effect, a person would have to take up to 100 times as much ivermectin as the dose approved for use in humans.
Some studies on ivermectin published in journals or on preprint servers ahead of peer review have demonstrated no benefits, or worsening of Covid-19 symptoms, after ivermectin use. Some have shown some benefit, such as shorter time to symptom resolution, reduction in inflammation, faster viral clearance and lower death rates.
im-506884

Ivermectin capsules, seen last year in the Philippines, where the drug was distributed in some places despite a lack of evidence to show it prevents or cures Covid-19.
PHOTO: ROLEX DELA PENA/SHUTTERSTOCK
But most studies showing positive effects had significant limitations such as small sample sizes or poorly defined outcomes, according to the NIH. Several studies on ivermectin have been withdrawn from publication, including a randomized controlled trial looking at 100 patients in Lebanon that was retracted by the journal Virusesdue to issues with the statistical analysis, according to the journal. Researchers at the NIH and Oxford University also are conducting large trials on the effectiveness of ivermectin, though results haven’t been published.
Dr. Mills said ivermectin could improve outcomes in Covid-19 patients who are fighting off certain parasitic diseases at the same time. But based on his team’s findings, he said, the drug doesn’t seem to have any effect on Covid-19 itself.
Dr. Mills and his colleagues also are studying other drugs that could be repurposed to work against Covid-19. Such drugs could be useful because their side effects are well known and they may be cheaper to deploy in poor countries than drugs like Merck & Co. and Ridgeback Biotherapeutics LP’s molnupiravir or Pfizer Inc.’s Paxlovid.

Related Video​

secondboosterisrael_512x288.jpg

Amid a surge in cases, some countries are handing out second booster shots. In Israel, early data suggest a fourth vaccine dose can increase antibodies against Covid-19, but not enough to prevent infections from Omicron. WSJ explains. Photo composite: Eve Hartley/WSJTHE WALL STREET JOURNAL INTERACTIVE EDITION
Merck said it has taken steps to make molnupiravir available in low- and middle-income countries, including allocating three million courses for distribution through aid groups and granting licenses to generic manufacturers. Pfizer said it was working to expand its supply chain and licensing production of Paxlovid through a United Nations program.
Dr. Mills and his collaborators have looked at 11 repurposed treatments against Covid-19, of which at least one has shown promise—fluvoxamine, which is commonly used to treat obsessive compulsive disorder and depression. They published the research in the Lancet Global Health in October, showing that Covid-19 patients who received fluvoxamine were less likely to require hospitalization than those who didn’t.
The researchers are looking at the effect in Covid-19 patients of combining fluvoxamine and an inhaled steroid, budesonide, as well as a drug called peginterferon lambda, which is used to treat chronic viral hepatitis
 


Setting up the big moment...........


Curious timing. Aren't they 100% vaxxed?

Hundreds of Millions of People Have Safely Received a COVID-19 Vaccine​


More than 558 million doses of COVID-19 vaccine had been given in the United States from December 14, 2020, through March 21, 2022. To view the current total number of COVID-19 vaccinations that have been administered in the United States, please visit the CDC COVID Data Tracker.
COVID-19 vaccines are safe and effective. COVID-19 vaccines were evaluated in tens of thousands of participants in clinical trials. The vaccines met the Food and Drug Administration’s (FDA’s) rigorous scientific standards for safety, effectiveness, and manufacturing quality needed to support emergency use authorization (EUA). Learn more about EUAs in this video.external icon
The Pfizer-BioNTech, Moderna, and Johnson & Johnson/Janssen COVID-19 vaccines will continue to undergo the most intensive safety monitoring in US history. This monitoring includes using both established and new safety monitoring systems to make sure that COVID-19 vaccines are safe.

Common Side Effects​

After COVID-19 vaccination, some people may feel ill, with symptoms like fever or tiredness for a day or two after receiving the vaccine. These symptoms are normal and are signs that the body is building immunity. Some people have no side effects. Others have reported common side effects after COVID-19 vaccination,such as:
  • Swelling, redness, and pain at the injection site
  • Fever
  • Headache
  • Tiredness
  • Muscle pain
  • Chills
  • Nausea

Serious Safety Problems Are Rare​

In rare cases, people have experienced serious health events after COVID-19 vaccination. Any health problem that happens after vaccination is considered an adverse event. An adverse event can be caused by the vaccine or can be caused by a coincidental event not related to the vaccine.
 

Hospitalizations in Largest Trial to Date​

Patients who got the antiparasitic drug didn’t fare better than those who received a placebo​

im-506883

Ivermectin got attention from celebrities including podcast host Joe Rogan, but researchers said they found no indication that it is clinically useful against Covid-19.
PHOTO: MIKE STEWART/ASSOCIATD PRESS
I By

Sarah Toy
Updated March 18, 2022 10:16 am ET

Researchers testing repurposed drugs against Covid-19 found that ivermectin didn’t reduce hospital admissions, in the largest trial yet of the effect of the antiparasitic on the disease driving the pandemic.
Ivermectin has received a lot of attention as a potential treatment for Covid-19 including from celebritiessuch as podcast host Joe Rogan. Most evidence has shown it to be ineffectiveagainst Covid-19 or has relied on data of poor quality, infectious-disease researchers said. Public-health authorities and researchers have for months said the drug hasn’t shown any benefit in treating the disease. Taking large doses of the drug is dangerous, the Food and Drug Administration has said.
The latest trial, of nearly 1,400 Covid-19 patients at risk of severe disease, is the largest to show that those who received ivermectin as a treatment didn’t fare better than those who received a placebo.

SHARE YOUR THOUGHTS​

How should the most recent studies on the efficacy of ivermectin against Covid-19 influence its use going forward? Join the conversation below.
“There was no indication that ivermectin is clinically useful,” said Edward Mills, one of the study’s lead researchers and a professor of health sciences at Canada’s McMaster University in Hamilton, Ontario. Dr. Mills on Friday plans to present the findings, which have been accepted for publication in a major peer-reviewed medical journal, at a public forum sponsored by the National Institutes of Health.
Dr. Mills and his colleagues looked at 1,358 adults who visited one of 12 clinics in the Minas Gerais region of Brazil with Covid-19 symptoms. The patients all had a positive rapid test for SARS-CoV-2, and were at risk of having a severe case for reasons including a history of diabetes, hypertension, cardiovascular disease or lung disease.
im-506882

Poster with the phrase, ‘We have ivermectin,’ at a pharmacy in Ceilândia, Brazil.
PHOTO: RICARDO JAYME/AGIF/ASSOCIATED PRESS
The researchers prescribed half of the patients a course of ivermectin pills for three days. The other half received a placebo. They tracked whether the patients were hospitalized within 28 days. The researchers also looked at whether patients on ivermectin cleared the virus from their bodies faster than those who received a placebo, whether their symptoms resolved sooner, whether they were in the hospital or on ventilators for less time and whether there was any difference in the death rates for the two groups.
To make sure they were being thorough, the researchers analyzed the data in three different ways. They looked at data from all patients; then analyzed data from patients who received ivermectin or a placebo 24 hours before they were hospitalized; and in a third review, looked at data from patients who said they had adhered strictly to their dosing schedule. In each scenario, they found ivermectin didn’t improve patient outcomes.
“This is the first large, prospective study that should really help put to rest ivermectin and not give any credibility to the use of it for Covid-19,” said Peter Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine, who reviewed the findings.
Ivermectin is used primarily to treat patients with certain parasitic diseases. Some doctors have been prescribing it to Covid-19 patients, and some people have been found ways to obtain ivermectin without a prescription. The drug has antiviral properties, but hasn’t been approved by the FDA to treat any viral infections.
Given its antiviral prospects, scientists early in the pandemic thought it could be a candidate for treating Covid-19. In June 2020, a group of researchers in Australia published a paper showing that large amounts of ivermectin could halt replication of the coronavirus in cell cultures. But there was a problem: To achieve that effect, a person would have to take up to 100 times as much ivermectin as the dose approved for use in humans.
Some studies on ivermectin published in journals or on preprint servers ahead of peer review have demonstrated no benefits, or worsening of Covid-19 symptoms, after ivermectin use. Some have shown some benefit, such as shorter time to symptom resolution, reduction in inflammation, faster viral clearance and lower death rates.
im-506884

Ivermectin capsules, seen last year in the Philippines, where the drug was distributed in some places despite a lack of evidence to show it prevents or cures Covid-19.
PHOTO: ROLEX DELA PENA/SHUTTERSTOCK
But most studies showing positive effects had significant limitations such as small sample sizes or poorly defined outcomes, according to the NIH. Several studies on ivermectin have been withdrawn from publication, including a randomized controlled trial looking at 100 patients in Lebanon that was retracted by the journal Virusesdue to issues with the statistical analysis, according to the journal. Researchers at the NIH and Oxford University also are conducting large trials on the effectiveness of ivermectin, though results haven’t been published.
Dr. Mills said ivermectin could improve outcomes in Covid-19 patients who are fighting off certain parasitic diseases at the same time. But based on his team’s findings, he said, the drug doesn’t seem to have any effect on Covid-19 itself.
Dr. Mills and his colleagues also are studying other drugs that could be repurposed to work against Covid-19. Such drugs could be useful because their side effects are well known and they may be cheaper to deploy in poor countries than drugs like Merck & Co. and Ridgeback Biotherapeutics LP’s molnupiravir or Pfizer Inc.’s Paxlovid.

Related Video​

secondboosterisrael_512x288.jpg

Amid a surge in cases, some countries are handing out second booster shots. In Israel, early data suggest a fourth vaccine dose can increase antibodies against Covid-19, but not enough to prevent infections from Omicron. WSJ explains. Photo composite: Eve Hartley/WSJTHE WALL STREET JOURNAL INTERACTIVE EDITION
Merck said it has taken steps to make molnupiravir available in low- and middle-income countries, including allocating three million courses for distribution through aid groups and granting licenses to generic manufacturers. Pfizer said it was working to expand its supply chain and licensing production of Paxlovid through a United Nations program.
Dr. Mills and his collaborators have looked at 11 repurposed treatments against Covid-19, of which at least one has shown promise—fluvoxamine, which is commonly used to treat obsessive compulsive disorder and depression. They published the research in the Lancet Global Health in October, showing that Covid-19 patients who received fluvoxamine were less likely to require hospitalization than those who didn’t.
The researchers are looking at the effect in Covid-19 patients of combining fluvoxamine and an inhaled steroid, budesonide, as well as a drug called peginterferon lambda, which is used to treat chronic viral hepatitis
 
For the covidians that keep citing disinformation on various evidentiary topics around safety and efficacy , you need to read this. Evidence Based Medicine as it exists today is broken and corrupt. I experience this first hand with the PI on the COVIDOUT ivermectin trial. I challenged him on twitter and he showed his corruption.

Guy was aloof as ****. Didn't understand anything about PK . Didn't care. The FDA told him to dispense the medication on empty stomach, and he did as ordered. The FDA told him it was ok to give an absurdly low dose of ivermectin up to 10 days post symptom onset. Of course the trial is going to fail. It's the same problem with all the trials. Apathetic , aloof and possibly corrupt investigators with a pre-existing negative bias, combined with a trial designed to fail. It's a recipe for disaster

 
For the covidians that keep citing disinformation on various evidentiary topics around safety and efficacy , you need to read this. Evidence Based Medicine as it exists today is broken and corrupt. I experience this first hand with the PI on the COVIDOUT ivermectin trial. I challenged him on twitter and he showed his corruption.

Guy was aloof as ****. Didn't understand anything about PK . Didn't care. The FDA told him to dispense the medication on empty stomach, and he did as ordered. The FDA told him it was ok to give an absurdly low dose of ivermectin up to 10 days post symptom onset. Of course the trial is going to fail. It's the same problem with all the trials. Apathetic , aloof and possibly corrupt investigators with a pre-existing negative bias, combined with a trial designed to fail. It's a recipe for disaster

Hundreds of Millions of People Have Safely Received a COVID-19 Vaccine​


More than 558 million doses of COVID-19 vaccine had been given in the United States from December 14, 2020, through March 21, 2022. To view the current total number of COVID-19 vaccinations that have been administered in the United States, please visit the CDC COVID Data Tracker.
COVID-19 vaccines are safe and effective. COVID-19 vaccines were evaluated in tens of thousands of participants in clinical trials. The vaccines met the Food and Drug Administration’s (FDA’s) rigorous scientific standards for safety, effectiveness, and manufacturing quality needed to support emergency use authorization (EUA). Learn more about EUAs in this video.external icon
The Pfizer-BioNTech, Moderna, and Johnson & Johnson/Janssen COVID-19 vaccines will continue to undergo the most intensive safety monitoring in US history. This monitoring includes using both established and new safety monitoring systems to make sure that COVID-19 vaccines are safe.

Common Side Effects​

After COVID-19 vaccination, some people may feel ill, with symptoms like fever or tiredness for a day or two after receiving the vaccine. These symptoms are normal and are signs that the body is building immunity. Some people have no side effects. Others have reported common side effects after COVID-19 vaccination,such as:
  • Swelling, redness, and pain at the injection site
  • Fever
  • Headache
  • Tiredness
  • Muscle pain
  • Chills
  • Nausea

Serious Safety Problems Are Rare​

In rare cases, people have experienced serious health events after COVID-19 vaccination. Any health problem that happens after vaccination is considered an adverse event. An adverse event can be caused by the vaccine or can be caused by a coincidental event not related to the vaccine.
 
For the covidians that keep citing disinformation on various evidentiary topics around safety and efficacy , you need to read this. Evidence Based Medicine as it exists today is broken and corrupt. I experience this first hand with the PI on the COVIDOUT ivermectin trial. I challenged him on twitter and he showed his corruption.

Guy was aloof as ****. Didn't understand anything about PK . Didn't care. The FDA told him to dispense the medication on empty stomach, and he did as ordered. The FDA told him it was ok to give an absurdly low dose of ivermectin up to 10 days post symptom onset. Of course the trial is going to fail. It's the same problem with all the trials. Apathetic , aloof and possibly corrupt investigators with a pre-existing negative bias, combined with a trial designed to fail. It's a recipe for disaster

Hospitalizations in Largest Trial to Date​

Patients who got the antiparasitic drug didn’t fare better than those who received a placebo​

im-506883

Ivermectin got attention from celebrities including podcast host Joe Rogan, but researchers said they found no indication that it is clinically useful against Covid-19.
PHOTO: MIKE STEWART/ASSOCIATD PRESS
I By

Sarah Toy
Updated March 18, 2022 10:16 am ET

Researchers testing repurposed drugs against Covid-19 found that ivermectin didn’t reduce hospital admissions, in the largest trial yet of the effect of the antiparasitic on the disease driving the pandemic.
Ivermectin has received a lot of attention as a potential treatment for Covid-19 including from celebritiessuch as podcast host Joe Rogan. Most evidence has shown it to be ineffectiveagainst Covid-19 or has relied on data of poor quality, infectious-disease researchers said. Public-health authorities and researchers have for months said the drug hasn’t shown any benefit in treating the disease. Taking large doses of the drug is dangerous, the Food and Drug Administration has said.
The latest trial, of nearly 1,400 Covid-19 patients at risk of severe disease, is the largest to show that those who received ivermectin as a treatment didn’t fare better than those who received a placebo.

SHARE YOUR THOUGHTS​

How should the most recent studies on the efficacy of ivermectin against Covid-19 influence its use going forward? Join the conversation below.
“There was no indication that ivermectin is clinically useful,” said Edward Mills, one of the study’s lead researchers and a professor of health sciences at Canada’s McMaster University in Hamilton, Ontario. Dr. Mills on Friday plans to present the findings, which have been accepted for publication in a major peer-reviewed medical journal, at a public forum sponsored by the National Institutes of Health.
Dr. Mills and his colleagues looked at 1,358 adults who visited one of 12 clinics in the Minas Gerais region of Brazil with Covid-19 symptoms. The patients all had a positive rapid test for SARS-CoV-2, and were at risk of having a severe case for reasons including a history of diabetes, hypertension, cardiovascular disease or lung disease.
im-506882

Poster with the phrase, ‘We have ivermectin,’ at a pharmacy in Ceilândia, Brazil.
PHOTO: RICARDO JAYME/AGIF/ASSOCIATED PRESS
The researchers prescribed half of the patients a course of ivermectin pills for three days. The other half received a placebo. They tracked whether the patients were hospitalized within 28 days. The researchers also looked at whether patients on ivermectin cleared the virus from their bodies faster than those who received a placebo, whether their symptoms resolved sooner, whether they were in the hospital or on ventilators for less time and whether there was any difference in the death rates for the two groups.
To make sure they were being thorough, the researchers analyzed the data in three different ways. They looked at data from all patients; then analyzed data from patients who received ivermectin or a placebo 24 hours before they were hospitalized; and in a third review, looked at data from patients who said they had adhered strictly to their dosing schedule. In each scenario, they found ivermectin didn’t improve patient outcomes.
“This is the first large, prospective study that should really help put to rest ivermectin and not give any credibility to the use of it for Covid-19,” said Peter Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine, who reviewed the findings.
Ivermectin is used primarily to treat patients with certain parasitic diseases. Some doctors have been prescribing it to Covid-19 patients, and some people have been found ways to obtain ivermectin without a prescription. The drug has antiviral properties, but hasn’t been approved by the FDA to treat any viral infections.
Given its antiviral prospects, scientists early in the pandemic thought it could be a candidate for treating Covid-19. In June 2020, a group of researchers in Australia published a paper showing that large amounts of ivermectin could halt replication of the coronavirus in cell cultures. But there was a problem: To achieve that effect, a person would have to take up to 100 times as much ivermectin as the dose approved for use in humans.
Some studies on ivermectin published in journals or on preprint servers ahead of peer review have demonstrated no benefits, or worsening of Covid-19 symptoms, after ivermectin use. Some have shown some benefit, such as shorter time to symptom resolution, reduction in inflammation, faster viral clearance and lower death rates.
im-506884

Ivermectin capsules, seen last year in the Philippines, where the drug was distributed in some places despite a lack of evidence to show it prevents or cures Covid-19.
PHOTO: ROLEX DELA PENA/SHUTTERSTOCK
But most studies showing positive effects had significant limitations such as small sample sizes or poorly defined outcomes, according to the NIH. Several studies on ivermectin have been withdrawn from publication, including a randomized controlled trial looking at 100 patients in Lebanon that was retracted by the journal Virusesdue to issues with the statistical analysis, according to the journal. Researchers at the NIH and Oxford University also are conducting large trials on the effectiveness of ivermectin, though results haven’t been published.
Dr. Mills said ivermectin could improve outcomes in Covid-19 patients who are fighting off certain parasitic diseases at the same time. But based on his team’s findings, he said, the drug doesn’t seem to have any effect on Covid-19 itself.
Dr. Mills and his colleagues also are studying other drugs that could be repurposed to work against Covid-19. Such drugs could be useful because their side effects are well known and they may be cheaper to deploy in poor countries than drugs like Merck & Co. and Ridgeback Biotherapeutics LP’s molnupiravir or Pfizer Inc.’s Paxlovid.

Related Video​

secondboosterisrael_512x288.jpg

Amid a surge in cases, some countries are handing out second booster shots. In Israel, early data suggest a fourth vaccine dose can increase antibodies against Covid-19, but not enough to prevent infections from Omicron. WSJ explains. Photo composite: Eve Hartley/WSJTHE WALL STREET JOURNAL INTERACTIVE EDITION
Merck said it has taken steps to make molnupiravir available in low- and middle-income countries, including allocating three million courses for distribution through aid groups and granting licenses to generic manufacturers. Pfizer said it was working to expand its supply chain and licensing production of Paxlovid through a United Nations program.
Dr. Mills and his collaborators have looked at 11 repurposed treatments against Covid-19, of which at least one has shown promise—fluvoxamine, which is commonly used to treat obsessive compulsive disorder and depression. They published the research in the Lancet Global Health in October, showing that Covid-19 patients who received fluvoxamine were less likely to require hospitalization than those who didn’t.
The researchers are looking at the effect in Covid-19 patients of combining fluvoxamine and an inhaled steroid, budesonide, as well as a drug called peginterferon lambda, which is used to treat chronic viral hepatitis
 

Hospitalizations in Largest Trial to Date​

Patients who got the antiparasitic drug didn’t fare better than those who received a placebo​

im-506883

Ivermectin got attention from celebrities including podcast host Joe Rogan, but researchers said they found no indication that it is clinically useful against Covid-19.
PHOTO: MIKE STEWART/ASSOCIATD PRESS
I By

Sarah Toy
Updated March 18, 2022 10:16 am ET

Researchers testing repurposed drugs against Covid-19 found that ivermectin didn’t reduce hospital admissions, in the largest trial yet of the effect of the antiparasitic on the disease driving the pandemic.
Ivermectin has received a lot of attention as a potential treatment for Covid-19 including from celebritiessuch as podcast host Joe Rogan. Most evidence has shown it to be ineffectiveagainst Covid-19 or has relied on data of poor quality, infectious-disease researchers said. Public-health authorities and researchers have for months said the drug hasn’t shown any benefit in treating the disease. Taking large doses of the drug is dangerous, the Food and Drug Administration has said.
The latest trial, of nearly 1,400 Covid-19 patients at risk of severe disease, is the largest to show that those who received ivermectin as a treatment didn’t fare better than those who received a placebo.

SHARE YOUR THOUGHTS​

How should the most recent studies on the efficacy of ivermectin against Covid-19 influence its use going forward? Join the conversation below.
“There was no indication that ivermectin is clinically useful,” said Edward Mills, one of the study’s lead researchers and a professor of health sciences at Canada’s McMaster University in Hamilton, Ontario. Dr. Mills on Friday plans to present the findings, which have been accepted for publication in a major peer-reviewed medical journal, at a public forum sponsored by the National Institutes of Health.
Dr. Mills and his colleagues looked at 1,358 adults who visited one of 12 clinics in the Minas Gerais region of Brazil with Covid-19 symptoms. The patients all had a positive rapid test for SARS-CoV-2, and were at risk of having a severe case for reasons including a history of diabetes, hypertension, cardiovascular disease or lung disease.
im-506882

Poster with the phrase, ‘We have ivermectin,’ at a pharmacy in Ceilândia, Brazil.
PHOTO: RICARDO JAYME/AGIF/ASSOCIATED PRESS
The researchers prescribed half of the patients a course of ivermectin pills for three days. The other half received a placebo. They tracked whether the patients were hospitalized within 28 days. The researchers also looked at whether patients on ivermectin cleared the virus from their bodies faster than those who received a placebo, whether their symptoms resolved sooner, whether they were in the hospital or on ventilators for less time and whether there was any difference in the death rates for the two groups.
To make sure they were being thorough, the researchers analyzed the data in three different ways. They looked at data from all patients; then analyzed data from patients who received ivermectin or a placebo 24 hours before they were hospitalized; and in a third review, looked at data from patients who said they had adhered strictly to their dosing schedule. In each scenario, they found ivermectin didn’t improve patient outcomes.
“This is the first large, prospective study that should really help put to rest ivermectin and not give any credibility to the use of it for Covid-19,” said Peter Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine, who reviewed the findings.
Ivermectin is used primarily to treat patients with certain parasitic diseases. Some doctors have been prescribing it to Covid-19 patients, and some people have been found ways to obtain ivermectin without a prescription. The drug has antiviral properties, but hasn’t been approved by the FDA to treat any viral infections.
Given its antiviral prospects, scientists early in the pandemic thought it could be a candidate for treating Covid-19. In June 2020, a group of researchers in Australia published a paper showing that large amounts of ivermectin could halt replication of the coronavirus in cell cultures. But there was a problem: To achieve that effect, a person would have to take up to 100 times as much ivermectin as the dose approved for use in humans.
Some studies on ivermectin published in journals or on preprint servers ahead of peer review have demonstrated no benefits, or worsening of Covid-19 symptoms, after ivermectin use. Some have shown some benefit, such as shorter time to symptom resolution, reduction in inflammation, faster viral clearance and lower death rates.
im-506884

Ivermectin capsules, seen last year in the Philippines, where the drug was distributed in some places despite a lack of evidence to show it prevents or cures Covid-19.
PHOTO: ROLEX DELA PENA/SHUTTERSTOCK
But most studies showing positive effects had significant limitations such as small sample sizes or poorly defined outcomes, according to the NIH. Several studies on ivermectin have been withdrawn from publication, including a randomized controlled trial looking at 100 patients in Lebanon that was retracted by the journal Virusesdue to issues with the statistical analysis, according to the journal. Researchers at the NIH and Oxford University also are conducting large trials on the effectiveness of ivermectin, though results haven’t been published.
Dr. Mills said ivermectin could improve outcomes in Covid-19 patients who are fighting off certain parasitic diseases at the same time. But based on his team’s findings, he said, the drug doesn’t seem to have any effect on Covid-19 itself.
Dr. Mills and his colleagues also are studying other drugs that could be repurposed to work against Covid-19. Such drugs could be useful because their side effects are well known and they may be cheaper to deploy in poor countries than drugs like Merck & Co. and Ridgeback Biotherapeutics LP’s molnupiravir or Pfizer Inc.’s Paxlovid.

Related Video​

secondboosterisrael_512x288.jpg

Amid a surge in cases, some countries are handing out second booster shots. In Israel, early data suggest a fourth vaccine dose can increase antibodies against Covid-19, but not enough to prevent infections from Omicron. WSJ explains. Photo composite: Eve Hartley/WSJTHE WALL STREET JOURNAL INTERACTIVE EDITION
Merck said it has taken steps to make molnupiravir available in low- and middle-income countries, including allocating three million courses for distribution through aid groups and granting licenses to generic manufacturers. Pfizer said it was working to expand its supply chain and licensing production of Paxlovid through a United Nations program.
Dr. Mills and his collaborators have looked at 11 repurposed treatments against Covid-19, of which at least one has shown promise—fluvoxamine, which is commonly used to treat obsessive compulsive disorder and depression. They published the research in the Lancet Global Health in October, showing that Covid-19 patients who received fluvoxamine were less likely to require hospitalization than those who didn’t.
The researchers are looking at the effect in Covid-19 patients of combining fluvoxamine and an inhaled steroid, budesonide, as well as a drug called peginterferon lambda, which is used to treat chronic viral hepatitis
This isn’t going to stop the theorists as the place that Dr. Mills (lead researcher) works for has a pretty large conflict of interest. Obviously this doesn’t indicate corruption by itself but it’s easy pickings for anyone looking for it.

“Human trials are set to begin for two next-generation COVID-19 vaccines developed by a team of scientists at McMaster University.”

 
This isn’t going to stop the theorists as the place that Dr. Mills (lead researcher) works for has a pretty large conflict of interest. Obviously this doesn’t indicate corruption by itself but it’s easy pickings for anyone looking for it.

“Human trials are set to begin for two next-generation COVID-19 vaccines developed by a team of scientists at McMaster University.”

'Bout time!

The NIH predicted in mid-2020 that the ten (10) intra-muscular vaccine vectors in development were not designed to reduce, much less stop, the spread, and even just effective herd immunity would be impossible with them, even if everyone received those vaccines.

Intra-nasal is not only what we've always known would be required, but that's why it was used in the movie Contagion too. Intra-muscualar mRNA has ended up being an extremely piss-poor vector against SARS-CoV-2.

That said ...

I don't trust the objectivity of the US Mass and Social Media that are 'fact checked' by government and its crony capitalism. Even when CDC, FDA and NIH experts are publicly stating things that are at odds with their own agencies ...

The US Mass and Social Media, with Big Tech enforcing it, ensure they are not heard!

Ergo ...


While only 4 of us think this is heading towards a 'National ID,' many of us do very much realize that trust has been eroded ... and just differ regarding to 'what level.'
 



Yeah. Brag about getting 4 shots in a year, free take-home tests and then not asking why any of this makes sense.
 
'Bout time!

The NIH predicted in mid-2020 that the ten (10) intra-muscular vaccine vectors in development were not designed to reduce, much less stop, the spread, and even just effective herd immunity would be impossible with them, even if everyone received those vaccines.

Intra-nasal is not only what we've always known would be required, but that's why it was used in the movie Contagion too. Intra-muscualar mRNA has ended up being an extremely piss-poor vector against SARS-CoV-2.

That said ...

I don't trust the objectivity of the US Mass and Social Media that are 'fact checked' by government and its crony capitalism. Even when CDC, FDA and NIH experts are publicly stating things that are at odds with their own agencies ...

The US Mass and Social Media, with Big Tech enforcing it, ensure they are not heard!

Ergo ...


While only 4 of us think this is heading towards a 'National ID,' many of us do very much realize that trust has been eroded ... and just differ regarding to 'what level.'
You mean 4 free tests over the 4 she is entitled to?

Once again let me spell this out in a language that MAYBE A NARCISSIST CAN READ

YOU ARE AN ANTI-VAXER, ANTI-GOVERNMENT, ANTI-BIG PHARMA CONSPIRACY THEORIST WHO IS INDIRECTLY RESPONSIBLE FOR MURDERING COUNTLESS INNOCENT PEOPLE DUE TO SPREADING MISINFORMATION HERE AND THROUGHOUT SOCIAL MEDIA. YOU LACK SELF-AWARENESS AND HAVE BEEN PROVEN TO BE WRONG TIME AND TIME AGAIN REGARDING COVID
AND VACCINES. YOUR INCREDIBLE LACK OF SELF-AWARENESS AND EXTREME NARCISSISM DOES NOT ALLOW YOU TO SEE THAT

ADDITIONALLY, THE ABOVE TRAITS HAVE MADE POSSIBLY A ONCE PROMISING CAREER INTO A COMPLETE FAILURE. YOU’RE INSECURE ABOUT THAT, BUT WE ARE NOT FOOLED BY YOU

YOU’RE AN UNHEALTHY 400lb MAN WITH A FAILED CAREER WHO
LIVES IN A SHACK IN RURAL ALABAMA. YOU ARE NOW AT BEST A PART-TIME I.T. SPECIALIST WHO PERFORMS ODD JOBS
WHEN YOU CAN GET ONE AND KEEP IT UNTIL THEY CAN’T STAND YOU.

READ THIS 10 TIMES!
 
And the 4th shot approval wasn't even voted on by outside experts. The FDA just did it without consultation.
 
And the 4th shot approval wasn't even voted on by outside experts. The FDA just did it without consultation.

Hundreds of Millions of People Have Safely Received a COVID-19 Vaccine​


More than 558 million doses of COVID-19 vaccine had been given in the United States from December 14, 2020, through March 21, 2022. To view the current total number of COVID-19 vaccinations that have been administered in the United States, please visit the CDC COVID Data Tracker.
COVID-19 vaccines are safe and effective. COVID-19 vaccines were evaluated in tens of thousands of participants in clinical trials. The vaccines met the Food and Drug Administration’s (FDA’s) rigorous scientific standards for safety, effectiveness, and manufacturing quality needed to support emergency use authorization (EUA). Learn more about EUAs in this video.external icon
The Pfizer-BioNTech, Moderna, and Johnson & Johnson/Janssen COVID-19 vaccines will continue to undergo the most intensive safety monitoring in US history. This monitoring includes using both established and new safety monitoring systems to make sure that COVID-19 vaccines are safe.

Common Side Effects​

After COVID-19 vaccination, some people may feel ill, with symptoms like fever or tiredness for a day or two after receiving the vaccine. These symptoms are normal and are signs that the body is building immunity. Some people have no side effects. Others have reported common side effects after COVID-19 vaccination,such as:
  • Swelling, redness, and pain at the injection site
  • Fever
  • Headache
  • Tiredness
  • Muscle pain
  • Chills
  • Nausea

Serious Safety Problems Are Rare​

In rare cases, people have experienced serious health events after COVID-19 vaccination. Any health problem that happens after vaccination is considered an adverse event. An adverse event can be caused by the vaccine or can be caused by a coincidental event not related to the vaccine.
 

Hospitalizations in Largest Trial to Date​

Patients who got the antiparasitic drug didn’t fare better than those who received a placebo​

im-506883

Ivermectin got attention from celebrities including podcast host Joe Rogan, but researchers said they found no indication that it is clinically useful against Covid-19.
PHOTO: MIKE STEWART/ASSOCIATD PRESS
I By

Sarah Toy
Updated March 18, 2022 10:16 am ET

Researchers testing repurposed drugs against Covid-19 found that ivermectin didn’t reduce hospital admissions, in the largest trial yet of the effect of the antiparasitic on the disease driving the pandemic.
Ivermectin has received a lot of attention as a potential treatment for Covid-19 including from celebritiessuch as podcast host Joe Rogan. Most evidence has shown it to be ineffectiveagainst Covid-19 or has relied on data of poor quality, infectious-disease researchers said. Public-health authorities and researchers have for months said the drug hasn’t shown any benefit in treating the disease. Taking large doses of the drug is dangerous, the Food and Drug Administration has said.
The latest trial, of nearly 1,400 Covid-19 patients at risk of severe disease, is the largest to show that those who received ivermectin as a treatment didn’t fare better than those who received a placebo.

SHARE YOUR THOUGHTS​

How should the most recent studies on the efficacy of ivermectin against Covid-19 influence its use going forward? Join the conversation below.
“There was no indication that ivermectin is clinically useful,” said Edward Mills, one of the study’s lead researchers and a professor of health sciences at Canada’s McMaster University in Hamilton, Ontario. Dr. Mills on Friday plans to present the findings, which have been accepted for publication in a major peer-reviewed medical journal, at a public forum sponsored by the National Institutes of Health.
Dr. Mills and his colleagues looked at 1,358 adults who visited one of 12 clinics in the Minas Gerais region of Brazil with Covid-19 symptoms. The patients all had a positive rapid test for SARS-CoV-2, and were at risk of having a severe case for reasons including a history of diabetes, hypertension, cardiovascular disease or lung disease.
im-506882

Poster with the phrase, ‘We have ivermectin,’ at a pharmacy in Ceilândia, Brazil.
PHOTO: RICARDO JAYME/AGIF/ASSOCIATED PRESS
The researchers prescribed half of the patients a course of ivermectin pills for three days. The other half received a placebo. They tracked whether the patients were hospitalized within 28 days. The researchers also looked at whether patients on ivermectin cleared the virus from their bodies faster than those who received a placebo, whether their symptoms resolved sooner, whether they were in the hospital or on ventilators for less time and whether there was any difference in the death rates for the two groups.
To make sure they were being thorough, the researchers analyzed the data in three different ways. They looked at data from all patients; then analyzed data from patients who received ivermectin or a placebo 24 hours before they were hospitalized; and in a third review, looked at data from patients who said they had adhered strictly to their dosing schedule. In each scenario, they found ivermectin didn’t improve patient outcomes.
“This is the first large, prospective study that should really help put to rest ivermectin and not give any credibility to the use of it for Covid-19,” said Peter Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine, who reviewed the findings.
Ivermectin is used primarily to treat patients with certain parasitic diseases. Some doctors have been prescribing it to Covid-19 patients, and some people have been found ways to obtain ivermectin without a prescription. The drug has antiviral properties, but hasn’t been approved by the FDA to treat any viral infections.
Given its antiviral prospects, scientists early in the pandemic thought it could be a candidate for treating Covid-19. In June 2020, a group of researchers in Australia published a paper showing that large amounts of ivermectin could halt replication of the coronavirus in cell cultures. But there was a problem: To achieve that effect, a person would have to take up to 100 times as much ivermectin as the dose approved for use in humans.
Some studies on ivermectin published in journals or on preprint servers ahead of peer review have demonstrated no benefits, or worsening of Covid-19 symptoms, after ivermectin use. Some have shown some benefit, such as shorter time to symptom resolution, reduction in inflammation, faster viral clearance and lower death rates.
im-506884

Ivermectin capsules, seen last year in the Philippines, where the drug was distributed in some places despite a lack of evidence to show it prevents or cures Covid-19.
PHOTO: ROLEX DELA PENA/SHUTTERSTOCK
But most studies showing positive effects had significant limitations such as small sample sizes or poorly defined outcomes, according to the NIH. Several studies on ivermectin have been withdrawn from publication, including a randomized controlled trial looking at 100 patients in Lebanon that was retracted by the journal Virusesdue to issues with the statistical analysis, according to the journal. Researchers at the NIH and Oxford University also are conducting large trials on the effectiveness of ivermectin, though results haven’t been published.
Dr. Mills said ivermectin could improve outcomes in Covid-19 patients who are fighting off certain parasitic diseases at the same time. But based on his team’s findings, he said, the drug doesn’t seem to have any effect on Covid-19 itself.
Dr. Mills and his colleagues also are studying other drugs that could be repurposed to work against Covid-19. Such drugs could be useful because their side effects are well known and they may be cheaper to deploy in poor countries than drugs like Merck & Co. and Ridgeback Biotherapeutics LP’s molnupiravir or Pfizer Inc.’s Paxlovid.

Related Video​

secondboosterisrael_512x288.jpg

Amid a surge in cases, some countries are handing out second booster shots. In Israel, early data suggest a fourth vaccine dose can increase antibodies against Covid-19, but not enough to prevent infections from Omicron. WSJ explains. Photo composite: Eve Hartley/WSJTHE WALL STREET JOURNAL INTERACTIVE EDITION
Merck said it has taken steps to make molnupiravir available in low- and middle-income countries, including allocating three million courses for distribution through aid groups and granting licenses to generic manufacturers. Pfizer said it was working to expand its supply chain and licensing production of Paxlovid through a United Nations program.
Dr. Mills and his collaborators have looked at 11 repurposed treatments against Covid-19, of which at least one has shown promise—fluvoxamine, which is commonly used to treat obsessive compulsive disorder and depression. They published the research in the Lancet Global Health in October, showing that Covid-19 patients who received fluvoxamine were less likely to require hospitalization than those who didn’t.
The researchers are looking at the effect in Covid-19 patients of combining fluvoxamine and an inhaled steroid, budesonide, as well as a drug called peginterferon lambda, which is used to treat chronic viral hepatitis
 
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